Gardner F T, Jones C E, Polk H C
Arch Surg. 1979 Aug;114(8):883-6. doi: 10.1001/archsurg.1979.01370320015002.
Surveys of the use of antimicrobial agents were conducted at three university-affiliated teaching hospitals to ascertain the current use of antibiotics associated with surgery and to compare this use to the presently accepted standards. The survey included 300 consecutive surgical patients representing three surgical specialities. Evaluation was based on accepted therapeutic criteria with respect to the presence of an infection, appropriate in vitro antibiotic sensitivity testing, and recognized forms of prophylaxis. The results of our survey disclosed that although nonuse was usually appropriate, more often than not use of antibiotics was inappropriate. Errors, in order of frequency, included (1) misjudgments in attempted prophylaxis of operative wound infection, such as failure to use preoperative administration or use in clean operations without implanted foreign bodies, such as prosthesis, and (2) attempted treatment of undefined and undiagnosed fever.
为确定与手术相关的抗生素当前使用情况，并将其与目前公认的标准进行比较，我们在三所大学附属医院开展了抗菌药物使用情况调查。该调查涵盖了代表三个外科专业的300例连续手术患者。评估依据是关于感染存在情况的公认治疗标准、适当的体外抗生素敏感性试验以及公认的预防形式。我们的调查结果显示，虽然通常不使用抗生素是合适的，但抗生素的使用往往并不恰当。按出现频率排序，错误包括：（1）在试图预防手术伤口感染时判断错误，例如未进行术前给药，或在无植入异物（如假体）的清洁手术中使用抗生素；（2）试图治疗不明原因和未确诊的发热。
