de Macedo D D, de Mattos J P, Borges T M
Arq Neuropsiquiatr. 1979 Mar;37(1):76-84. doi: 10.1590/s0004-282x1979000100011.
A case of transverse myelopathy in systemic lupus erythematosus with subacute onset and fatal course is reported. A review of the literature is done and clinical, laboratorial, therapeutics and pathological aspects are discussed. The authors call attention to the poor results of therapy and discuss the participation of immunological factors leaving to demyelination which are, aside the classical vascular involvement, the probable mechanisms in the neurological manifestations of systemic lupus erythematosus. The authors believe that, in their case, such a demyelinative mechanism was responsible for the clinical picture, although a necroscopic examination was not allowed.
报告了1例系统性红斑狼疮伴亚急性起病和致命病程的横贯性脊髓病病例。对文献进行了回顾,并讨论了临床、实验室、治疗和病理方面。作者提请注意治疗效果不佳的情况,并讨论了免疫因素参与导致脱髓鞘的情况,除了经典的血管受累外,这些因素可能是系统性红斑狼疮神经表现的发病机制。作者认为,在他们的病例中,尽管未进行尸检,但这种脱髓鞘机制导致了临床表现。