维生素E与幼猫氧诱导性视网膜病变。II. 玻璃体新生血管形成的阻断

Vitamin E in kitten oxygen-induced retinopathy. II. Blockage of vitreal neovascularization.

作者信息

Phelps D L, Rosenbaum A L

出版信息

Arch Ophthalmol. 1979 Aug;97(8):1522-6. doi: 10.1001/archopht.1979.01020020184021.

DOI:10.1001/archopht.1979.01020020184021

Abstract

The effect of vitamin E (tocopherol) on oxygen-induced retinopathy was studied in the kitten after a quantitative scoring system was developed for their India ink injected retinal flat preparations. In 75 previously described kittens exposed to two or three days of oxygen from day 3, treatment from day 1 with vitamin E or placebo disclosed that kittens treated with vitamin E had less retinopathy. Theories of the mechanism of action of vitamin E would predict that, if given only after the oxygen exposure, vitamin E should be ineffective. This was tested in 37 kittens with placebo or drug begun only after withdrawal from oxygen. Unexpectedly, significantly less intravitreal neovascularization was found in kittens treated with vitamin E after oxygen exposure.

摘要

在为小猫注射印度墨水的视网膜扁平制剂建立了定量评分系统之后，研究了维生素E（生育酚）对氧诱导性视网膜病变的影响。在75只先前描述的小猫中，从第3天开始暴露于氧气中两到三天，从第1天开始用维生素E或安慰剂治疗，结果显示接受维生素E治疗的小猫视网膜病变较少。维生素E作用机制的理论预测，如果仅在暴露于氧气后给予维生素E，它应该是无效的。在37只小猫中进行了测试，这些小猫仅在停止吸氧后才开始使用安慰剂或药物。出乎意料的是，在暴露于氧气后接受维生素E治疗的小猫中，玻璃体内新生血管形成明显较少。