血液透析对慢性肾衰竭患者骨骼的影响。
Effects of haemodialysis on bone in chronic renal failure.
作者信息
Bishop M C, Woods C G, Oliver D O, Ledingham J G, Smith R, Tibbutt D A
出版信息
Br Med J. 1972 Sep 16;3(5828):664-7. doi: 10.1136/bmj.3.5828.664.
Quantitative histological studies have been done on 80 sequential bone biopsies taken at yearly intervals from 37 patients with chronic renal failure on long-term haemodialysis treatment. Twenty-three patients were studied at the start of dialysis, and in about half the bone was abnormal. During dialysis mean osteoid area and the maximum number of unmineralized osteoid lamellae increased, and mineralized bone area decreased. The loss of bone during dialysis was also reflected in reduction of the width of individual trabeculae. These trends were less obvious in patients already established on dialysis at the time of the initial biopsy. The course of osteitis fibrosa appeared to be unaffected by dialysis.
对37例接受长期血液透析治疗的慢性肾衰竭患者每年进行一次的80份连续骨活检标本进行了定量组织学研究。23例患者在透析开始时接受研究，约半数患者的骨有异常。透析期间，平均类骨质面积和未矿化类骨质板的最大数量增加，矿化骨面积减少。透析期间的骨质流失还表现为单个小梁宽度减小。这些趋势在初次活检时已开始透析的患者中不太明显。纤维性骨炎的病程似乎不受透析影响。
Zotero 插件