Garnier M J, Marshall F N, DAvison K J, Lepreau F J
Lancet. 1975 Feb 15;1(7903):383-6. doi: 10.1016/s0140-6736(75)91292-1.
In 1958-72, 985 cases of tetanus (excluding tetanus of the newborn) were admitted to a hospital in Haiti. Mortality was 22%, and in later years (1966-72) mortality fell. During this period the dosage of tetanus antitoxin was lowered to 10,000 units and, for sedation, diazepam has satisfactorily replaced multiple-drug regimens used in earlier years. However, good nursing, including close attention to breathing, is probably the most important item in treatment. As a result of a programme of maternal immunisation, admissions for neonatal tetanus have fallen, and mortality for this condition has been reduced to 26%.
1958年至1972年期间，海地一家医院收治了985例破伤风患者（不包括新生儿破伤风）。死亡率为22%，在随后几年（1966年至1972年）死亡率有所下降。在此期间，破伤风抗毒素的剂量降至10000单位，并且在镇静方面，地西泮已令人满意地取代了早年使用的多种药物联合治疗方案。然而，良好的护理，包括密切关注呼吸，可能是治疗中最重要的一项。由于实施了孕产妇免疫计划，新生儿破伤风的入院病例数有所下降，这种疾病的死亡率已降至26%。
