Smith-Erichsen N, Bø G
Br J Anaesth. 1979 Jun;51(6):475-9. doi: 10.1093/bja/51.6.475.
We have investigated the effect of airway closure on fluid balance in the isolated, perfused rabbit lung in which the alveolar, pleural and vascular pressures could be regulated independently. The rate of filtration into the interstitial space was monitored by continuous weighing. A reduction in pleural pressure of 0.5 kPa with open airways increased fluid filtration by 0.11 g min-1. Reduction in pleural pressure of 0.5 kPa with the main airways closed reduced the alveolar pressure by 0.4 kPa and increased fluid filtration by 0.86 g minp1. We concluded that the pleural pressure is transmitted poorly to the alveolar interstitial space in the normal lung with open airways. However, airway closure allows the pleural pressure to be transmitted almost completely to this interstitium, with interstitial oedema as a possible consequence.
我们研究了气道关闭对离体灌注兔肺液体平衡的影响，在该实验中，肺泡压、胸膜压和血管压可独立调节。通过连续称重监测液体滤入间质间隙的速率。气道开放时，胸膜压降低0.5 kPa可使液体滤过增加0.11 g·min⁻¹。主气道关闭时，胸膜压降低0.5 kPa可使肺泡压降低0.4 kPa，并使液体滤过增加0.86 g·min⁻¹。我们得出结论，在气道开放的正常肺中，胸膜压向肺泡间质间隙的传递较差。然而，气道关闭可使胸膜压几乎完全传递至该间质，可能导致间质水肿。
