Gregoretti S, Drummond G B, Milic-Emili J
Br J Anaesth. 1979 Jun;51(6):503-11. doi: 10.1093/bja/51.6.503.
Tidal volume (VT), minute ventilation (VE), the duration of inspiratats anaesthetized with 0.7%, 1% and 1.5% (inspired) trichloroethylene (TCE). The tracheal cannula was occluded at intervals at the start of inspiration and the tracheal pressure was measured to assess the force of contraction of the respiratory muscles. Anaesthesia with TCE 0.7% was associated with an increase in VE, a reduction in VT, and a marked increase in respiratory frequency and mean inspiratory flow rate, but PaCO2 values did not differ significantly from those in conscious animals. Ventilation was also greater than in conscious animals during anaesthesia with TCE 1%. TCE 1.5% caused a significantly greater PaCO2 than in conscious animals. All concentrations of TCE caused a reduction in the ventilatory response to carbon dioxide, measured by the steady-state method. Cervical vagal section did not abolish the tachypnoea caused by TCE.
潮气量（VT）、分钟通气量（VE）、用0.7%、1%和1.5%（吸入）三氯乙烯（TCE）麻醉时的吸气持续时间。在吸气开始时定期阻塞气管插管，并测量气管压力以评估呼吸肌的收缩力。0.7%的TCE麻醉导致VE增加、VT降低、呼吸频率和平均吸气流量显著增加，但动脉血二氧化碳分压（PaCO2）值与清醒动物相比无显著差异。在1%的TCE麻醉期间，通气量也高于清醒动物。1.5%的TCE导致PaCO2比清醒动物显著升高。所有浓度的TCE均导致通过稳态法测量的对二氧化碳的通气反应降低。颈迷走神经切断术并未消除TCE引起的呼吸急促。
