Kashani M, Haigh A L
Q J Exp Physiol Cogn Med Sci. 1975 Oct;60(4):285-98. doi: 10.1113/expphysiol.1975.sp002322.
The influence of vagotomy on resting arterial blood gases (PaCO2 and PaO2) and on the ventilatory responses to hypercapnia and hypoxia was studied in three different species of anaesthetized animals. After bilateral cervical vagotomy resting PaCO2 generally declined. In the dog, where this was studied more fully, resting PaCO2 declined significantly (8-13 +/- 0-67 mm Hg) over several hours, but PaO2 changes were not significant. After vagotomy tidal volume (VT), but not frequency (f), increased with increasing chemical drive. It is concluded that the increase in frequency in response to increased CO2 or decreased O2 is dependent on the vagal mechanisms. Minute volume, fractional inspiratory CO2 (VE, FICO2) and minute volume, fractional inspiratory O2 (VE, FIO2) relationships have been determined. Although vagotomy may not decrease the response of minute volume of ventilation in the lower part of VE, FICO2 curves (mild hypercapnia), it flattened the upper parts of the curves in sheep and rabbits, and to a lesser extent in dogs; it seemed that there was little species difference in this respect. Ventilatory responses to graded hypoxia were close to or slightly higher than pre-vagotomy values throughout the VE, FIO2 curves in all animals.
在三种不同的麻醉动物中研究了迷走神经切断术对静息动脉血气（PaCO₂ 和 PaO₂）以及对高碳酸血症和低氧血症通气反应的影响。双侧颈迷走神经切断术后，静息 PaCO₂ 通常会下降。在对其进行更全面研究的狗中，静息 PaCO₂ 在数小时内显著下降（8 - 13 ± 0 - 67 mmHg），但 PaO₂ 变化不显著。迷走神经切断术后，潮气量（VT）随化学驱动增加而增加，但呼吸频率（f）不变。得出的结论是，对 CO₂ 增加或 O₂ 减少的频率增加依赖于迷走神经机制。已确定了每分通气量、吸入 CO₂ 分数（VE，FICO₂）和每分通气量、吸入 O₂ 分数（VE，FIO₂）之间的关系。虽然迷走神经切断术可能不会降低 VE，FICO₂ 曲线下部（轻度高碳酸血症）的每分通气量反应，但它使绵羊和兔子曲线的上部变平，在狗中程度较小；在这方面似乎几乎没有物种差异。在所有动物的整个 VE，FIO₂ 曲线中，对分级低氧血症的通气反应接近或略高于迷走神经切断术前的值。
