氢氯噻嗪在充血性心力衰竭患者中的药代动力学。
Pharmacokinetics of hydrochlorothiazide in patients with congestive heart failure.
作者信息
Beermann B, Groschinsky-Grind M
出版信息
Br J Clin Pharmacol. 1979 Jun;7(6):579-83. doi: 10.1111/j.1365-2125.1979.tb04646.x.
Abstract
- Hydrochlorothiazide (HCT, 50-75 mg) was administered orally to seven patients with cardiac failure. 2. Plasma levels and urinary concentration of HCT were determined by GLC. 3. The gastrointestinal uptake of the diuretic in three patients was reduced to approximately half that seen in healthy controls. 4. Plasma halflife of HCT was correlated with endogenous creatinine clearance. 5. Pharmacokinetics of HCT are considerably changed in cardiac failure.
摘要
- 对7例心力衰竭患者口服给予氢氯噻嗪（HCT，50 - 75毫克）。2. 采用气相色谱法测定HCT的血浆水平和尿液浓度。3. 3例患者中该利尿剂的胃肠道吸收降至健康对照者的约一半。4. HCT的血浆半衰期与内生肌酐清除率相关。5. 心力衰竭时HCT的药代动力学有显著改变。
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