Barbhaiya R H, Patel R B, Corrick-West H P, Joslin R S, Welling P G
Biopharm Drug Dispos. 1982 Oct-Dec;3(4):329-36. doi: 10.1002/bdd.2510030406.
The bioavailability and pharmacokinetics of two hydrochlorothiazide products were compared following single 50 mg oral doses to 20 healthy male volunteers. Plasma and urine were assayed for hydrochlorothiazide by a specific and sensitive HPLC method. Plasma profiles of hydrochlorothiazide were adequately described by a triexponential function. The bioavailability of hydrochlorothiazide from the two brands did not differ significantly as judged by the values of Cmax, tmax, AUC0 leads to infinity, mean residence time, variance of residence time, and urinary excretion of unchanged drug. Close similarity was observed between urinary excretion rates and concentrations of drug in plasma.
对20名健康男性志愿者单次口服50毫克后，比较了两种氢氯噻嗪产品的生物利用度和药代动力学。采用特异且灵敏的高效液相色谱法测定血浆和尿液中的氢氯噻嗪。氢氯噻嗪的血浆浓度曲线可用三指数函数充分描述。根据Cmax、tmax、AUC0至无穷大、平均驻留时间、驻留时间方差以及原形药物的尿排泄量判断，两种品牌氢氯噻嗪的生物利用度无显著差异。观察到尿排泄率与血浆中药物浓度之间有密切相似性。
