序贯麻醉中使用的混合激动剂-拮抗剂镇痛药的副作用。

Side-effects of mixed agonist-antagonist analgesics used in sequential anaesthesia.

作者信息

Devaux C, Schoepffler P, Gauthier-Lafaye J P

出版信息

Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):323S-326S. doi: 10.1111/j.1365-2125.1979.tb04708.x.

DOI:10.1111/j.1365-2125.1979.tb04708.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429303/

Abstract

1 Mixed agonist-antagonist analgesics have analgesic action but also possess a range of side-effects. 2 Narcotic antagonists do not reverse the non-specific effects of opiates. 3 Under certain circumstances the effects of agonists and mixed agonist-antagonists can be additive. 4 Chronic dosage of mixed agonist-antagonists leads to a lower level of dependence than that observed with the standard narcotics. 5 Mixed agonist-antagonists may not antagonize the respiratory effects of narcotics and may result in potentiation of such depression.

摘要

混合激动剂 - 拮抗剂类镇痛药具有镇痛作用，但也有一系列副作用。
麻醉拮抗剂不能逆转阿片类药物的非特异性作用。
在某些情况下，激动剂和混合激动剂 - 拮抗剂的作用可能会相加。
长期使用混合激动剂 - 拮抗剂导致的依赖程度低于标准麻醉药品。
混合激动剂 - 拮抗剂可能无法拮抗麻醉药品的呼吸作用，可能会增强这种抑制作用。

相似文献

1

Side-effects of mixed agonist-antagonist analgesics used in sequential anaesthesia.序贯麻醉中使用的混合激动剂-拮抗剂镇痛药的副作用。

Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):323S-326S. doi: 10.1111/j.1365-2125.1979.tb04708.x.

2

Mixed agonist-antagonist opiates and physical dependence.混合激动剂-拮抗剂阿片类药物与身体依赖性

Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):291S-296S. doi: 10.1111/j.1365-2125.1979.tb04703.x.

3

Dependence characteristics and risk assessment of agonist-antagonist analgesics.激动剂-拮抗剂镇痛药的依赖性特征与风险评估

Drug Alcohol Depend. 1987 Dec;20(4):317-27. doi: 10.1016/0376-8716(87)90005-6.

4

[New developments and findings in the field of opiates, opioids, opiate receptors and complete and partial opiate antagonists].[阿片类药物、阿片样物质、阿片受体以及完全和部分阿片拮抗剂领域的新进展与新发现]

Anaesthesiol Reanim. 1990;15(3):138-44.

5

Clinical pharmacology of antagonists of narcotic-induced respiratory depression. A brief review.麻醉性镇痛药所致呼吸抑制拮抗剂的临床药理学。简要综述。

Acute Care. 1988;12 Suppl 1:70-6.

6

Benefit-risk ratio of agonist-antagonist analgesics.激动剂-拮抗剂镇痛药的获益-风险比。

Drug Alcohol Depend. 1987 Dec;20(4):385-93. doi: 10.1016/0376-8716(87)90011-1.

7

Reversal of fentanyl/fluanisone neuroleptanalgesia in the rabbit using mixed agonist/antagonist opioids.使用混合激动剂/拮抗剂阿片类药物逆转兔体内芬太尼/氟哌利多神经安定镇痛作用。

Lab Anim. 1989 Apr;23(2):147-55. doi: 10.1258/002367789780863655.

8

History and development of mixed opioid agonists, partial agonists and antagonists.混合阿片类激动剂、部分激动剂和拮抗剂的历史与发展

Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):273S-279S. doi: 10.1111/j.1365-2125.1979.tb04700.x.

9

STUDIES OF ANALGESIC DRUGS. VIII. A NARCOTIC ANTAGONIST ANALGESIC WITHOUT PSYCHOTOMIMETIC EFFECTS.镇痛药研究。VIII. 一种无拟精神病作用的麻醉性拮抗镇痛药。

J Pharmacol Exp Ther. 1964 Feb;143:157-64.

10

THE ANALGESIC EFFICACY AND RESPIRATORY EFFECTS IN MAN OF A BENZOMORPHAN "NARCOTIC ANTAGNOST".一种苯并吗啡烷“麻醉拮抗剂”对人体的镇痛效果及呼吸影响

J Pharmacol Exp Ther. 1964 Apr;144:12-6.

本文引用的文献

1

A double blind comparison of buprenorphine and morphine in conscious subjects following administration by the intramuscular route.布托啡诺与吗啡在清醒受试者中经肌肉注射给药后的双盲对照研究。

Acta Anaesthesiol Belg. 1976;27(3):171-81.

2

Respiratory and circulatory effects of intravenous butorphanol and morphine.静脉注射布托啡诺和吗啡对呼吸及循环系统的影响。

Clin Pharmacol Ther. 1976 Jun;19(6):738-45. doi: 10.1002/cpt1976196738.

3

Pharmacological and clinical importance of narcotic antagonists and mixed antagonists--use in cardiology.

Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):309S-311S. doi: 10.1111/j.1365-2125.1979.tb04705.x.

4

Butorphanol: a review of its pharmacological properties and therapeutic efficacy.

Drugs. 1978 Dec;16(6):473-505. doi: 10.2165/00003495-197816060-00001.

5

Animal and molecular pharmacology of mixed agonist-antagonist analgesic drugs.

Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):281S-286S. doi: 10.1111/j.1365-2125.1979.tb04701.x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。