Animal and molecular pharmacology of mixed agonist-antagonist analgesic drugs.
作者信息
Rance M J
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):281S-286S. doi: 10.1111/j.1365-2125.1979.tb04701.x.
Abstract
1 The pharmacology of analgesic drugs with mixed agonist-antagonist action is reviewed in the light of the theory of drug action at single and multiple receptors. 2 Evidence for a heterogeneous population of opiate receptors in mammalian brain and in isolated tissue preparations is discussed. 3 The unusual pharmacological and pharmacokinetic profiles of the oripavine derivative buprenorphine are discussed in relation to the action of the drug at a molecular level.
摘要
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本文引用的文献
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A comparison of heat and pressure analgesiometric methods in rats.大鼠热和压力镇痛测量方法的比较。
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Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics.弱镇痛药和非镇痛药对苯醌诱发小鼠扭体反应频率的拮抗作用。
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Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex.麻醉性镇痛药与大鼠大脑皮质突触质膜部分之间的立体特异性相互作用。
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Opiate receptor: demonstration in nervous tissue.阿片受体：在神经组织中的显示
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