Shelley W B, Wood M G
Br J Dermatol. 1979 Jun;100(6):649-55. doi: 10.1111/j.1365-2133.1979.tb08068.x.
A new post-surgical form of recurrent herpes simplex is described. It appeared as an erythematous bulla at sites of recurrent herpes from which the prior epidermal lesion had been transversely excised. Histologically, it was characterized by a lesion-free epidermis, a large subepidermal bulla, and a marked inflammatory response in the uppermost dermis, complete with diagnostic multinucleate giant cells. It is postulated that epidermal surgery leaves the area immune to future direct herpetic involvement of the epidermis because it denervates the epidermis. The possibility is raised that such dermal forms of herpes may also occur in the natural course of the disease.
本文描述了一种新型的手术后复发性单纯疱疹。它表现为复发性疱疹部位的红斑性水疱，先前的表皮病变已被横向切除。组织学上，其特征为无病变的表皮、大的表皮下水疱以及最上层真皮层明显的炎症反应，并伴有典型的多核巨细胞。据推测，表皮手术使该区域对未来表皮的直接疱疹感染具有免疫力，因为它使表皮去神经化。由此提出一种可能性，即这种真皮型疱疹在疾病的自然病程中也可能发生。
