与白内障及白内障手术相关的细胞介导免疫
Cell mediated immunity in relation to cataract and cataract surgery.
作者信息
Brinkman C J, Broekhuyse R M
出版信息
Br J Ophthalmol. 1979 May;63(5):301-5. doi: 10.1136/bjo.63.5.301.
Two groups of patients suffering from cataract were investigated by the lymphocyte stimulation test. One group was tested before and the other after cataract surgery. Human (total) lens crystallins and bovine alpha crystallin were used as the antigens. Lymphocytes of healthy persons showed practically no positive stimulation with either antigen. Of the patients tested before operation 38% reacted positively with lens crystallins and 15% with alpha crystallin. This difference in sensitisation suggests a leakage of lenticular antigens other than alpha crystallin out of the lens during cataract progression. Extracapsular lens extraction caused an increase in the number of patients reacting positively with lens crystallins and alpha crystallin as compared to patients not operated upon. Intracapsular lens extraction on the other hand resulted in less sensitisation to lens crystallins as compared to patients not operated upon.
通过淋巴细胞刺激试验对两组白内障患者进行了研究。一组在白内障手术前进行测试，另一组在白内障手术后进行测试。使用人（全）晶状体蛋白和牛α晶状体蛋白作为抗原。健康人的淋巴细胞对这两种抗原几乎没有阳性刺激反应。在手术前接受测试的患者中，38%对晶状体蛋白呈阳性反应，15%对α晶状体蛋白呈阳性反应。这种致敏差异表明，在白内障进展过程中，除α晶状体蛋白外的晶状体抗原从晶状体中泄漏出来。与未接受手术的患者相比，囊外晶状体摘除术使对晶状体蛋白和α晶状体蛋白呈阳性反应的患者数量增加。另一方面，与未接受手术的患者相比，囊内晶状体摘除术导致对晶状体蛋白的致敏性降低。
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