Sandberg H O, Closs O
Scand J Immunol. 1979;10(6):549-54. doi: 10.1111/j.1365-3083.1979.tb01389.x.
By radioimmunoassay the occurrence of antibodies against alpha, beta and gamma crystallins was examined in sera from groups of patients with clear lenses, cataracts or lens injuries. In about half of the sera from each group low anti alpha crystallin activity was found. No significant difference in antibody activity was found between the groups. Antibody activity against beta or gamma crystallins was not detected in any of the sera. Four patients with lens damage were followed for 2 years; two of them developed uveitis and showed increasing anti alpha crystallin activity. It is suggested that in man immunological tolerance to lens crystallins is normally present.
通过放射免疫测定法，检测了晶状体清晰、患有白内障或晶状体损伤的患者组血清中针对α、β和γ晶状体蛋白的抗体的出现情况。在每组约一半的血清中发现了低抗α晶状体蛋白活性。各组之间未发现抗体活性有显著差异。在任何血清中均未检测到针对β或γ晶状体蛋白的抗体活性。对4名晶状体损伤患者进行了2年的随访；其中2人发生了葡萄膜炎，并显示出抗α晶状体蛋白活性增加。提示在人类中，对晶状体蛋白的免疫耐受性通常是存在的。
