慢性药物治疗对14C-L-多巴肠膜转运的影响。
Effect of chronic drug treatment on intestinal membrane transport of 14 C-L-dopa.
作者信息
Rivera-Calimlim L
出版信息
Br J Pharmacol. 1972 Dec;46(4):708-13. doi: 10.1111/j.1476-5381.1972.tb06895.x.
Abstract
- By the use of the everted jejunal sac it was shown that chronic oral treatment of rats with various drugs can either increase or decrease the mucosal transport of (14)C-L-DOPA or alter its serosal/tissue ratio.2. (14)C-L-DOPA transport was significantly increased in rats that were chronically treated with L-DOPA and diminished in those that were treated with chlorpromazine and phenobarbitone.3. Chronic treatment with amantadine and neomycin did not affect (14)C-L-DOPA intestinal transport, although direct addition of amantadine to the medium, significantly increased (14)C-L-DOPA transport in everted sacs of nontreated rats. Addition of neomycin directly to the medium did not affect (14)C-L-DOPA transport.4. The possible mechanisms of these findings and their clinical significance are discussed.
摘要
通过使用外翻空肠囊实验表明，用各种药物对大鼠进行长期口服治疗，可增加或降低（14）C-L-多巴的黏膜转运，或改变其浆膜/组织比率。
长期用L-多巴治疗的大鼠，（14）C-L-多巴转运显著增加；而用氯丙嗪和苯巴比妥治疗的大鼠，（14）C-L-多巴转运减少。
金刚烷胺和新霉素的长期治疗不影响（14）C-L-多巴的肠道转运，尽管将金刚烷胺直接添加到培养基中，可显著增加未治疗大鼠外翻囊中（14）C-L-多巴的转运。直接向培养基中添加新霉素不影响（14）C-L-多巴的转运。
讨论了这些发现的可能机制及其临床意义。
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