给予苯海索的大鼠中氯丙嗪吸收受损。
Impaired absorption of chlorpromazine in rats given trihexyphenidyl.
作者信息
Rivera-Calimlim L
出版信息
Br J Pharmacol. 1976 Mar;56(3):301-5. doi: 10.1111/j.1476-5381.1976.tb07642.x.
Abstract
1 The absorption and tissue distribution of orally administered [14C]-chlorpromazine (CPZ) were compared in trihexyphenidyl (THP; Artane)-treated and control rats. 2 Total radioactivity (CPZ) in the plasma and brain of rats treated with THP was significantly lower whereas total radioactivity in the stomach was significantly higher than in rats not previously treated with THP. 3 Gastric emptying in rats treated with THP was significantly delayed as measured by gastric clearance of a marker [14C]-polyethylene glycol. 4 Transport of [14C]-CPZ in everted sacs was not affected by treatment with THP. 5 Metabolism of [14C]-CPZ by liver homogenates was not affected by treatment with THP. 6 The relationship of delayed gastric emptying in THP-treated rats and their lower plasma and brain levels of [14C]-CPZ after oral administration is discussed.
摘要
- 比较了在接受苯海索（THP；安坦）治疗的大鼠和对照大鼠中口服[14C] - 氯丙嗪（CPZ）的吸收和组织分布情况。2. 接受THP治疗的大鼠血浆和脑中的总放射性（CPZ）显著降低，而胃中的总放射性显著高于未接受过THP治疗的大鼠。3. 用标记物[14C] - 聚乙二醇的胃清除率测量，接受THP治疗的大鼠胃排空显著延迟。4. THP治疗对[14C] - CPZ在翻转肠囊中的转运没有影响。5. THP治疗对肝匀浆中[14C] - CPZ的代谢没有影响。6. 讨论了THP治疗的大鼠胃排空延迟与其口服给药后血浆和脑中[14C] - CPZ水平较低之间的关系。
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本文引用的文献
1
Metabolic activity of the small intestine of the rat and golden hamster (Mesocricetus auratus).大鼠和金黄仓鼠（Mesocricetus auratus）小肠的代谢活性。
J Physiol. 1954 Jan;123(1):126-30. doi: 10.1113/jphysiol.1954.sp005037.
2
Absorption and metabolism of L-dopa by the human stomach.左旋多巴在人体胃部的吸收与代谢
Eur J Clin Invest. 1971 May;1(5):313-20. doi: 10.1111/j.1365-2362.1971.tb00637.x.
3
Delayed absorption of phenylbutazone caused by desmethylimipramine in humans.去甲丙咪嗪导致人体中保泰松吸收延迟。
Eur J Pharmacol. 1970 May;10(2):239-42. doi: 10.1016/0014-2999(70)90278-5.
4
The physiological disposition of chlorpromazine in the rat and dog.氯丙嗪在大鼠和狗体内的生理处置
Proc Soc Exp Biol Med. 1970 May;134(1):314-8. doi: 10.3181/00379727-134-34784.
5
Reversal of some therapeutic effects of an antipsychotic agent by an antiparkinsonism drug.一种抗帕金森病药物对抗精神病药物某些治疗作用的逆转。
J Nerv Ment Dis. 1973 Jul;157(1):50-8. doi: 10.1097/00005053-197307000-00007.
6
Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption.胃排空的药理学调节：丙胺太林和甲氧氯普胺对扑热息痛吸收的影响。
Br Med J. 1973 Mar 10;1(5853):587-9. doi: 10.1136/bmj.1.5853.587.
7
Effect of chronic drug treatment on intestinal membrane transport of 14 C-L-dopa.慢性药物治疗对14C-L-多巴肠膜转运的影响。
Br J Pharmacol. 1972 Dec;46(4):708-13. doi: 10.1111/j.1476-5381.1972.tb06895.x.
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Clin Pharmacol Ther. 1973 Nov-Dec;14(6):978-86. doi: 10.1002/cpt1973146978.
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