异丁酸负荷大鼠尿液中S(+)-3-羟基异丁酸的分离与鉴定
Isolation and identification of S(+)-3-hydroxyisobutyric acid in the urine of rats loaded with isobutyric acid.
作者信息
Amster J, Tanaka K
出版信息
Biochim Biophys Acta. 1979 Jul 18;585(4):643-4. doi: 10.1016/0304-4165(79)90196-x.
PMID:465545
Abstract
3-Hydroxyisobutyric acid has been isolated from the urine of rats loaded with sodium isobutyrate. An optical rotation measurement of the methyl ester derivative shows this compound to be the S(+) stereoisomer. This is the same stereoisomer that has been previously identified in cultures of bacteria incubated with ammonium isobutyrate (Aberhart, D.J. (1977) Bioorg. Chem. 6, 191--201).
摘要
3-羟基异丁酸已从用异丁酸钠负荷的大鼠尿液中分离出来。对甲酯衍生物的旋光测量表明该化合物为S(+)立体异构体。这与先前在用异丁酸铵培养的细菌培养物中鉴定出的立体异构体相同（阿伯哈特，D.J.（1977年）《生物有机化学》6，191 - 201）。
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