93株鸡胚致死孤儿病毒在雏鸡粪便排泄模式中的年龄相关变化。
Age-associated changes in fecal excretion patterns of strain 93 chick embryo lethal orphan virus in chicks.
作者信息
Clemmer D I
出版信息
Infect Immun. 1972 Jan;5(1):60-4. doi: 10.1128/iai.5.1.60-64.1972.
Oral incoulation of chickens with strain 93 (chick embryo lethal orphan) virus produced a subclinical infection of the gastrointestinal tract. The pattern of fecal virus excretion in birds infected at 4 or more weeks of age (adult pattern) differed from that in chicks infected when newly hatched (juvenile pattern). By comparison with the juvenile pattern, the adult pattern was characterized by lower peak titers of fecal virus, earlier decline in virus titer, and shorter duration of excretion. Quantitative studies on hatchmates infected at various ages showed that these characteristics are established sequentially with age: lower peak titers were observed in birds infected at 2 to 4 days of age; early decline in titer was first observed in birds infected at 14 days of age; and curtailed excretion was observed in birds infected at 21 days of age. Possible mechanisms operative in the autosterilization process are discussed.
用93株（鸡胚致死孤儿）病毒经口接种鸡可导致胃肠道的亚临床感染。4周龄及以上感染的禽类（成年模式）粪便病毒排泄模式与刚孵化时感染的雏鸡（幼年模式）不同。与幼年模式相比，成年模式的特征是粪便病毒峰值滴度较低、病毒滴度下降较早且排泄持续时间较短。对不同年龄感染的同窝雏鸡进行的定量研究表明，这些特征随年龄依次形成：2至4日龄感染的禽类峰值滴度较低；14日龄感染的禽类首次观察到滴度早期下降；21日龄感染的禽类排泄减少。文中讨论了在自动清除过程中可能起作用的机制。
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