金黄色葡萄球菌蛋白A在体外对免疫复合物抑制抗体依赖性细胞毒性作用的中和作用。
Neutralization of immune complex inhibition of antibody dependent cellular cytotoxicity in vitro by Staphylococcus-aureus protein A.
作者信息
Cowan F M, Klein D L, Armstrong G R, Pearson J W
出版信息
Biomedicine. 1979 Feb;30(1):23-7.
Staphylococcus-aureus protein A (SPA) incubated with sera containing immune complexes and effector cells increases antibody dependent cellular cytotoxicity (ADCC)and rosette formation. The enhanced ADCC and rosetting is due to SPA functioning as an IgG Fc cellular receptor. SPA binds to the Fc portion of Igg and has much greater affinity for immune complexes than free IgG. SPA bound immune complexes are blocked from attaching to the Fc cellular receptors via a competitive inhibition which neutralizes the inhibitory effect of these complexes on ADCC and rosette formation.
与含有免疫复合物和效应细胞的血清一起孵育的金黄色葡萄球菌蛋白A（SPA）可增强抗体依赖性细胞毒性（ADCC）和玫瑰花结形成。ADCC和玫瑰花结形成增强是由于SPA作为IgG Fc细胞受体发挥作用。SPA与IgG的Fc部分结合，对免疫复合物的亲和力远高于游离IgG。通过竞争性抑制作用，阻止了SPA结合的免疫复合物附着于Fc细胞受体，从而消除了这些复合物对ADCC和玫瑰花结形成的抑制作用。
Zotero 插件