γ-羟基丁酸对小鼠纹状体酪胺、多巴胺和高香草酸的影响。
The effect of gamma-hydroxybutyrate on mouse striatal tyramine, dopamine and homovanillic acid.
作者信息
Juorio A V
出版信息
Br J Pharmacol. 1982 Mar;75(3):447-50. doi: 10.1111/j.1476-5381.1982.tb09160.x.
Abstract
1 The concentrations of p- and m-tyramine, dopamine and homovanillic acid were measured in the mouse striatum following the subcutaneous injection of gamma-hydroxybutyrate; their control levels were 19.8, 6.3, 9600 and 1130 ng/g respectively. 2 The administration of 500-1000 mg/kg of gamma-hydroxybutyrate produced a reduction in p-tyramine that lasted at least 8 h. m-Tyramine and dopamine were significantly increased for at least 4 h. The levels of homovanillic acid were increased at 1 and 2 h after drug administration. 3 There experiments strongly suggest that the increases in dopamine turnover produced by gamma-hydroxybutyrate caused reciprocal changes in striatal tyramine that are similar to those produced by drug or treatment that increase dopamine turnover and tyrosine hydroxylase activity.
摘要
- 在皮下注射γ-羟基丁酸后，测定了小鼠纹状体中对-酪胺、间-酪胺、多巴胺和高香草酸的浓度；它们的对照水平分别为19.8、6.3、9600和1130 ng/g。2. 给予500 - 1000 mg/kg的γ-羟基丁酸会使对-酪胺减少，且至少持续8小时。间-酪胺和多巴胺显著增加至少4小时。给药后1小时和2小时高香草酸水平升高。3. 这些实验有力地表明，γ-羟基丁酸引起的多巴胺周转率增加导致纹状体酪胺发生相反变化，这与增加多巴胺周转率和酪氨酸羟化酶活性的药物或治疗所产生的变化相似。
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