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The metabolism of isoprenaline has been studied in man and dog following intravenous and oral or intra-duodenal administration.2. Intravenous isoprenaline was excreted largely unchanged in urine in both species. Only one-third of the radioactivity in urine was in the form of the O-methyl metabolite.3. After oral doses in man or intraduodenal doses in dogs, plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine.4. Catechol-O-methyl transferase may be less important than Uptake(2) in limiting the pharmacological action of isoprenaline.5. Pharmacological response (heart-rate increase) was related to plasma concentration of isoprenaline only after rapid intravenous injections. In dogs, following prolonged infusion or intraduodenal doses, heart rate returned to base-line values when plasma concentrations of isoprenaline were high.

已在人和狗身上研究了静脉注射以及口服或十二指肠内给药后异丙肾上腺素的代谢情况。
静脉注射的异丙肾上腺素在这两个物种的尿液中大多以原形排出。尿液中只有三分之一的放射性是以O - 甲基代谢物的形式存在。
在人经口服给药或狗经十二指肠内给药后，血浆放射性几乎完全以结合型异丙肾上腺素的形式存在，且这种代谢物占尿液中放射性的80%以上。
在限制异丙肾上腺素的药理作用方面，儿茶酚 - O - 甲基转移酶可能不如摄取（2）重要。
仅在快速静脉注射后，药理反应（心率增加）才与血浆异丙肾上腺素浓度相关。在狗身上，长时间输注或十二指肠内给药后，当血浆异丙肾上腺素浓度很高时，心率会恢复到基线值。

The metabolism of isoprenaline has been studied in man and dog following intravenous and oral or intra-duodenal administration.2. Intravenous isoprenaline was excreted largely unchanged in urine in both species. Only one-third of the radioactivity in urine was in the form of the O-methyl metabolite.3. After oral doses in man or intraduodenal doses in dogs, plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine.4. Catechol-O-methyl transferase may be less important than Uptake(2) in limiting the pharmacological action of isoprenaline.5. Pharmacological response (heart-rate increase) was related to plasma concentration of isoprenaline only after rapid intravenous injections. In dogs, following prolonged infusion or intraduodenal doses, heart rate returned to base-line values when plasma concentrations of isoprenaline were high.

已在人和狗身上研究了静脉注射以及口服或十二指肠内给药后异丙肾上腺素的代谢情况。
静脉注射的异丙肾上腺素在这两个物种的尿液中大多以原形排出。尿液中只有三分之一的放射性是以O - 甲基代谢物的形式存在。
在人经口服给药或狗经十二指肠内给药后，血浆放射性几乎完全以结合型异丙肾上腺素的形式存在，且这种代谢物占尿液中放射性的80%以上。
在限制异丙肾上腺素的药理作用方面，儿茶酚 - O - 甲基转移酶可能不如摄取（2）重要。
仅在快速静脉注射后，药理反应（心率增加）才与血浆异丙肾上腺素浓度相关。在狗身上，长时间输注或十二指肠内给药后，当血浆异丙肾上腺素浓度很高时，心率会恢复到基线值。

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