垂体切除及随后用绵羊催乳素或牛生长激素替代疗法对兔乳腺乳糖合成酶活性的影响。
The effect of hypophysectomy and subsequent replacement therapy with sheep prolactin or bovine growth hormone on the lactose synthetase activity of rabbit mammary gland.
作者信息
Jones E A, Cowie A T
出版信息
Biochem J. 1972 Dec;130(4):997-1002. doi: 10.1042/bj1300997.
Abstract
- The effects of hypophysectomy and replacement therapy with sheep prolactin and bovine growth hormone on the lactose synthetase activity of the mammary glands of lactating rabbits were studied. 2. There was an approximately fourfold decline in the lactose synthetase activity of homogenates calculated on a DNA basis within 6-7 days of hypophysectomy. Prolactin reversed this decline but growth hormone had no effect. 3. Changes in the properties of a particulate fraction isolated from the glands indicated that a decline in the effective concentration of alpha-lactalbumin was one factor contributing to the decreased lactose synthetase activity after hypophysectomy. 4. As the changes in lactose output produced by hypophysectomy and prolactin therapy are much greater than the changes in total lactose synthetase activity it is concluded that the activity of this enzyme is not the main factor controlling lactose output under these conditions.
摘要
- 研究了垂体切除以及用绵羊催乳素和牛生长激素替代疗法对泌乳兔乳腺乳糖合成酶活性的影响。2. 垂体切除后6 - 7天内，以DNA为基础计算，匀浆中乳糖合成酶活性下降了约四倍。催乳素可逆转这种下降，但生长激素无此作用。3. 从腺体分离出的颗粒部分性质的变化表明，α-乳白蛋白有效浓度的下降是垂体切除后乳糖合成酶活性降低的一个因素。4. 由于垂体切除和催乳素疗法引起的乳糖产量变化远大于总乳糖合成酶活性的变化，因此得出结论，在这些条件下，该酶的活性不是控制乳糖产量的主要因素。
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