大鼠体内的乳糖合成以及窝仔数和营养不良的影响。
Lactose synthesis in the rat, and the effects of litter size and malnutrition.
作者信息
Wilde C J, Kuhn N J
出版信息
Biochem J. 1979 Aug 15;182(2):287-94. doi: 10.1042/bj1820287.
Abstract
- The rate of lactose synthesis per g of mammary tissue, measured in vivo by a radioisotopic technique, rose 13-fold between parturition and day 16 of lactation in the rat, but was unaffected by wide variation in litter size. 2. The increase reflected a greater tissue content of galactosyltransferase (EC 2.4.1.22), and was augmented by a rise in the total weight of mammary tissue. Superimposed on this were unpredictable changes in the functional efficiency of the enzyme. 3. Lactose synthesis in 14-day-lactating rats, permitted only 76% of the food intake of paired control rats over the previous 3 weeks, showed a pronounced diurnal variation at an overall rate markedly below that in control rats. 4. Such nutritional deficiency did not affect the tissue content of galactosyltransferase, but impaired its functional efficiency in a manner reversed by renewed feeding or by the preparation and incubation of acini in vitro. 5. Plasma insulin concentrations decreased at parturition and with increasing litter size, and remained relatively unchanged during lactation and malnutrition.
摘要
- 通过放射性同位素技术在体内测量，每克乳腺组织的乳糖合成速率在大鼠分娩至泌乳第16天期间增加了13倍，但不受窝仔数大幅变化的影响。2. 这种增加反映了半乳糖基转移酶（EC 2.4.1.22）的组织含量更高，并且乳腺组织总重量的增加使其进一步增强。在此基础上，酶的功能效率出现了不可预测的变化。3. 在14天泌乳期的大鼠中，其在过去3周内的食物摄入量仅为配对对照大鼠的76%，乳糖合成呈现出明显的昼夜变化，总体速率明显低于对照大鼠。4. 这种营养缺乏并不影响半乳糖基转移酶的组织含量，但会损害其功能效率，重新喂食或在体外制备并培养腺泡可使其功能效率恢复。5. 血浆胰岛素浓度在分娩时以及随着窝仔数增加而降低，在泌乳和营养不良期间保持相对不变。
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