肾脏微粒体部分中钾离子刺激且钠离子依赖的二磷酸腺苷-三磷酸腺苷交换活性。
Potassium ion-stimulated and sodium ion-dependent adenosine diphosphate-adenosine triphosphate exchange activity in a kidney microsomal fraction.
作者信息
Banerjee S P, Wong S M
出版信息
Biochem J. 1972 Sep;129(3):775-9. doi: 10.1042/bj1290775.
Abstract
- K(+) did not affect the Mg(2+)-dependent transphosphorylation but markedly increased the Na(+)-stimulated ADP-ATP exchange rate mediated by a microsomal fraction from guinea-pig kidney. 2. Rb(+), Cs(+), NH(4) (+) and Li(+) were equally effective in stimulating the Na(+)-dependent ADP-ATP exchange activity. 3. Treatment of the microsomal fraction with N-ethylmaleimide or increased concentrations of Mg(2+) prevented stimulation of the Na(+)-dependent exchange reaction by K(+). 4. Ouabain (2.5mum) inhibited ATP hydrolysis by 33% but did not decrease the K(+)-stimulated Na(+)-dependent ADP-ATP exchange rate. 5. A possible mechanism for stimulation of exchange activity by K(+) is discussed.
摘要
- 钾离子（K(+)）不影响镁离子（Mg(2+)）依赖的转磷酸化作用，但显著提高了由豚鼠肾脏微粒体部分介导的钠离子（Na(+)）刺激的二磷酸腺苷-三磷酸腺苷（ADP-ATP）交换速率。2. 铷离子（Rb(+)）、铯离子（Cs(+)）、铵离子（NH(4) (+)）和锂离子（Li(+)）在刺激钠离子依赖的ADP-ATP交换活性方面同样有效。3. 用N-乙基马来酰亚胺处理微粒体部分或增加镁离子浓度可阻止钾离子对钠离子依赖的交换反应的刺激作用。4. 哇巴因（2.5微摩尔）抑制三磷酸腺苷（ATP）水解33%，但不降低钾离子刺激的钠离子依赖的ADP-ATP交换速率。5. 讨论了钾离子刺激交换活性的一种可能机制。
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