Allin R, Russell V A, Lamm M C, Taljaard J J
Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, South Africa.
Neurochem Res. 1988 Oct;13(10):937-42. doi: 10.1007/BF00970765.
Monoamine concentrations were low in the rostral area of the nucleus accumbens. Their distributions were not identical. Differences were observed in the medial area. DA concentrations were high in both medial and caudal areas. Noradrenaline (NA) and serotonin (5-HT) concentrations were considerably lower than the dopamine (DA) concentration. The NA concentration was highest in the caudal area of the nucleus accumbens and the (5-HT) concentration was highest in the ventrocaudal area. There was a rostrocaudal decrease in the 3,4-dihydroxyphenylacetic acid (DOPAC)/DA and 5-hydroxyindole-3-acetic acid (5-HIAA)/5-HT ratios. Uptake of [3H]DA and [14C]choline was lowest in the rostral area. The K+-stimulated release of [14C]acetylcholine (ACh) was also lowest rostrally, but there was no rostrocaudal difference in the K+-stimulated release of [3H]DA. These results provide further evidence of the heterogeneity of the nucleus accumbens.
伏隔核吻侧区域的单胺浓度较低。它们的分布并不相同。在内侧区域观察到了差异。多巴胺（DA）浓度在中间和尾侧区域均较高。去甲肾上腺素（NA）和5-羟色胺（5-HT）浓度明显低于多巴胺（DA）浓度。NA浓度在伏隔核尾侧区域最高，而5-HT浓度在腹尾侧区域最高。3,4-二羟基苯乙酸（DOPAC）/DA和5-羟基吲哚-3-乙酸（5-HIAA）/5-HT比值存在吻尾递减。[3H]DA和[14C]胆碱的摄取在吻侧区域最低。K +刺激的[14C]乙酰胆碱（ACh）释放同样在吻侧最低，但K +刺激的[3H]DA释放不存在吻尾差异。这些结果为伏隔核的异质性提供了进一步的证据。
