Jan J E, Hill R H, Low M D
Can Med Assoc J. 1972 Oct 7;107(7):623-5.
A study of 170 patients with juvenile rheumatoid arthritis and a review of the literature indicate that this disease can significantly affect the central nervous system. Signs of CNS dysfunction were observed in 13 children. During the acute toxic stages the EEG is abnormal in many cases. Other manifestations of toxic encephalopathy such as irritability, drowsiness, stupor, convulsions and marked meningismus may be evident in severe cases. Meningitis is often suspected but ruled out by the finding of normal CSF. Steroids can rapidly improve the condition of these children. If ;unexplained' seizures occur during the chronic stage, the diagnosis of cerebral vasculitis should be entertained.
一项对170例青少年类风湿性关节炎患者的研究及文献综述表明，这种疾病可显著影响中枢神经系统。13名儿童出现了中枢神经系统功能障碍的体征。在急性中毒阶段，许多病例的脑电图异常。严重病例可能出现中毒性脑病的其他表现，如易怒、嗜睡、昏迷、惊厥和明显的颈项强直。常怀疑有脑膜炎，但脑脊液检查正常可排除。类固醇可迅速改善这些儿童的病情。如果在慢性阶段出现“不明原因”的惊厥，则应考虑诊断为脑血管炎。
