Hanka L J
Cancer Treat Rep. 1979 Jun;63(6):1133-6.
An in vitro system was developed to detect antimetabolites in fermentation liquors of soil microorganisms. This system effectively uncovers antimetabolites of purines and pyrimidines and of selected amino acids with established differences in their biosynthesis by normal cells versus certain malignant cells. Currently these amino acids include: L-asparagine, L-aspartic acid, L-glutamine, L-cysteine (cystine), L-methionine, L-arginine, L-histidine, L-tyrosine, L-phenylalanine, L-tryptophan, L-threonine, and L-serine. It is expected that these antimetabolites could be useful either alone or in combination with specific depleting enzymes in the treatment of malignancies where such an imbalance was established.
开发了一种体外系统来检测土壤微生物发酵液中的抗代谢物。该系统能有效发现嘌呤、嘧啶以及特定氨基酸的抗代谢物，这些抗代谢物在正常细胞与某些恶性细胞的生物合成过程中存在既定差异。目前这些氨基酸包括：L-天冬酰胺、L-天冬氨酸、L-谷氨酰胺、L-半胱氨酸（胱氨酸）、L-蛋氨酸、L-精氨酸、L-组氨酸、L-酪氨酸、L-苯丙氨酸、L-色氨酸、L-苏氨酸和L-丝氨酸。预计这些抗代谢物单独使用或与特定的消耗酶联合使用，在已确定存在这种失衡的恶性肿瘤治疗中可能会有用。
