乙醇对分离的大鼠肝细胞中氯乙烯代谢的抑制作用。

Ethanol inhibition of vinyl chloride metabolism in isolated rat hepatocytes.

作者信息

Hultmark D, Sundh K, Johansson L, Arrhenius E

出版信息

Chem Biol Interact. 1979 Apr;25(1):1-6. doi: 10.1016/0009-2797(79)90064-4.

DOI:10.1016/0009-2797(79)90064-4

Abstract

Isolated rat liver cells convert [14C]vinyl chloride into non-volatile metabolites. The metabolism is not increased by in vivo pretreatment with phenobarbital. It is sensitive to inhibition by ethanol, which at a concentration of 4 mM inhibits vinyl chloride metabolism to 50% in hepatocyte suspensions. The metabolic activity is NADPH-dependent and is localized in the microsomal fraction of the liver. The enzyme is also strongly inhibited by tetrahydrofuran, indicating that it could be identical to an ethanol-inducible cytochrome P-450 described in the literature [1].

摘要

分离的大鼠肝细胞可将[14C]氯乙烯转化为非挥发性代谢产物。苯巴比妥的体内预处理不会增加这种代谢作用。它对乙醇抑制敏感，在肝细胞悬液中，4 mM浓度的乙醇可将氯乙烯代谢抑制50%。这种代谢活性依赖于NADPH，且定位于肝脏的微粒体部分。该酶也受到四氢呋喃的强烈抑制，这表明它可能与文献[1]中描述的乙醇诱导型细胞色素P-450相同。

相似文献

1

Ethanol inhibition of vinyl chloride metabolism in isolated rat hepatocytes.乙醇对分离的大鼠肝细胞中氯乙烯代谢的抑制作用。

Chem Biol Interact. 1979 Apr;25(1):1-6. doi: 10.1016/0009-2797(79)90064-4.

2

Cytochrome P-450 and the metabolism of vinyl chloride.细胞色素P - 450与氯乙烯的代谢

Cancer Lett. 1976 Nov;2(2):109-13. doi: 10.1016/s0304-3835(76)80019-5.

3

Liver microsomal uptake of (14C)vinyl chloride and transformation to protein alkylating metabolites in vitro.体外肝脏微粒体对（14C）氯乙烯的摄取及向蛋白质烷基化代谢物的转化

Toxicol Appl Pharmacol. 1976 Sep;37(3):461-71. doi: 10.1016/0041-008x(76)90208-8.

4

Covalent protein binding of vinyl chloride metabolites during co-incubation of freshly isolated hepatocytes and hepatic sinusoidal cells of rats.大鼠新鲜分离的肝细胞和肝窦细胞共同孵育期间氯乙烯代谢产物的共价蛋白结合

Arch Toxicol Suppl. 1983;6:266-70. doi: 10.1007/978-3-642-69083-9_49.

5

Roles of 2-haloethylene oxides and 2-haloacetaldehydes derived from vinyl bromide and vinyl chloride in irreversible binding to protein and DNA.由溴乙烯和氯乙烯衍生的2-卤代环氧乙烷和2-卤代乙醛在与蛋白质和DNA不可逆结合中的作用。

Cancer Res. 1981 Nov;41(11 Pt 1):4391-8.

6

Metabolism of [14C]- and [36C]-labeled vinyl chloride in vivo and in vitro.体内和体外[14C] - 和[36C] - 标记氯乙烯的代谢

Biochem Pharmacol. 1979 Mar 1;28(5):589-96. doi: 10.1016/0006-2952(79)90140-0.

7

Formation of 3,N4-ethenocytidine moieties in RNA by vinyl chloride metabolities in vitro and in vivo.氯乙烯代谢产物在体外和体内使RNA中形成3,N4-乙烯胞苷部分。

Arch Toxicol. 1978 Jan 25;39(3):235-40. doi: 10.1007/BF00368232.

8

Disposition of (1,2-14C) vinyl chloride in the rat.大鼠体内（1,2-¹⁴C）氯乙烯的分布情况。

Arch Toxicol. 1976 Jun 8;35(3):153-62. doi: 10.1007/BF00293562.

9

Contrasting effects of 1,1,1-trichloroethane on [14C]vinyl chloride metabolism and activation in hepatic microsomes from phenobarbital- and isoniazid-treated rats.1,1,1-三氯乙烷对苯巴比妥和异烟肼处理大鼠肝微粒体中[14C]氯乙烯代谢及活化的对比作用。

Toxicol Appl Pharmacol. 1993 Mar;119(1):17-22. doi: 10.1006/taap.1993.1039.

10

Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde.氯乙烯活化为共价结合代谢物：2-氯环氧乙烷和2-氯乙醛的作用。

Biochemistry. 1979 Nov 13;18(23):5177-82. doi: 10.1021/bi00590a023.

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