Salmon A G
Cancer Lett. 1976 Nov;2(2):109-13. doi: 10.1016/s0304-3835(76)80019-5.
The oxidation of vinyl chloride to non-volatile products is dependent on NADPH and microsomal enzymes. The addition of vinyl chloride to microsomes causes a Type 1 spectra shift, similar to that seen for phenobarbital [11[ which indicates the direct involvement of a cytochrome P-450 species; this difference spectrum is characteristic of substrate binding to this type of enzyme. A glutathione conjugate is probably formed, perhaps via a reactive intermediate.
氯乙烯氧化生成非挥发性产物依赖于NADPH和微粒体酶。向微粒体中添加氯乙烯会导致1型光谱位移，类似于苯巴比妥所观察到的情况[11]，这表明细胞色素P - 450种类直接参与其中；这种差示光谱是底物与这类酶结合的特征。可能会形成谷胱甘肽缀合物，也许是通过活性中间体形成的。
