静脉注射NAB 365（克仑特罗）和特布他林治疗运动诱发性支气管痉挛（EIB）。

Intravenous NAB 365 (clenbuterol) and terbutaline in exercise-induced bronchospasm (EIB).

作者信息

Del Bono N, Quartieri F, Vibelli C

出版信息

Clin Allergy. 1979 May;9(3):277-82. doi: 10.1111/j.1365-2222.1979.tb01554.x.

DOI:10.1111/j.1365-2222.1979.tb01554.x

Abstract

In a single-blind, placebo-controlled, cross-over study, the effects of intravenous 20 micrograms NAB 365 (clenbuterol) and intravenous 250 microgram terbutaline were compared in nine asthmatic patients with bronchospasm induced by exercise. The exercise consisted of treadmill running. The two beta-adrenergic bronchodilator drugs effectively prevented post-exercise bronchospasm in eight of the nine patients. The effects were superior to those in the untreated group and in the placebo-treated group. Six of the patients treated with terbutaline complained of adverse reactions (tremor, palpitation, tachycardia). No adverse reactions were observed after clenbuterol.

摘要

在一项单盲、安慰剂对照的交叉研究中，对9名因运动诱发支气管痉挛的哮喘患者比较了静脉注射20微克NAB 365（克仑特罗）和静脉注射250微克特布他林的效果。运动为在跑步机上跑步。两种β-肾上腺素能支气管扩张剂药物在9名患者中的8名有效预防了运动后支气管痉挛。其效果优于未治疗组和安慰剂治疗组。6名接受特布他林治疗的患者出现了不良反应（震颤、心悸、心动过速）。使用克仑特罗后未观察到不良反应。