Di Gioacchino M, Mezzetti A, Mancini M, Guglielmi M D, Lo Medico E, Proietti Franceschilli G, Marzio L, Cuccurullo F
Respiration. 1987;51(3):205-13. doi: 10.1159/000195203.
The protective effect of clenbuterol on exercise-induced asthma was studied in 14 patients with aspecific bronchial hyperreactivity. The selectivity of clenbuterol for beta 2-receptors was also studied. Patients were selected according to spirometric criteria: reduced dynamic indexes of respiratory function after exercise and, particularly, forced expiratory volume at 1 s (FEV1) decreased by at least 20% compared with initial values. A polycardiographic study was simultaneously carried out for the evaluation of systolic time intervals and polycardiographic indexes (Weissler index, Blumberger index and QT/QS2 index). After the preliminary measurements (C1), oral clenbuterol was started (0.02 mg X 2/day) and measurements were repeated after 30 (CII) and 60 days (CIII) of therapy. During treatment, physical exercise did not significantly influence the indexes of respiratory function (FEV1 decreased by 4.7 +/- 5.8 and 9.8 +/- 10.5% in CII and CIII with respect to initial values). Similarly systolic time intervals and polycardiographic indexes did not change significantly with respect to the initial values. A small increase in heart rate at rest was observed in CII (+ 7%, p less than 0.05): however, no significant changes were recorded in CIII compared with the initial values. Clenbuterol thus seems to offer an effective protection against exercise-induced asthma without the negative effects on the cardiovascular system which may arise from activation of beta 1-adrenergic receptors.
对14例具有特异性支气管高反应性的患者研究了克仑特罗对运动诱发哮喘的保护作用。还研究了克仑特罗对β2受体的选择性。根据肺量计标准选择患者：运动后呼吸功能的动态指标降低，尤其是1秒用力呼气量（FEV1）与初始值相比至少降低20%。同时进行多心电图研究以评估收缩期时间间期和多心电图指标（魏斯勒指数、布伦伯格指数和QT/QS2指数）。在初步测量（C1）后，开始口服克仑特罗（0.02mg×2/天），并在治疗30天（CII）和60天（CIII）后重复测量。治疗期间，体育锻炼对呼吸功能指标没有显著影响（与初始值相比，CII和CIII中FEV1分别下降4.7±5.8%和9.8±10.5%）。同样，收缩期时间间期和多心电图指标与初始值相比没有显著变化。在CII中观察到静息心率略有增加（+7%，p<0.05）：然而，与初始值相比，CIII中未记录到显著变化。因此，克仑特罗似乎能有效预防运动诱发的哮喘，而不会因β1肾上腺素能受体激活而对心血管系统产生负面影响。
