猫离体气管平滑肌中的药物相互作用。

Drug interactions in cat isolated tracheal smooth muscle.

Mitchell H W, Denborough M A

Clin Exp Pharmacol Physiol. 1979 May-Jun;6(3):249-57. doi: 10.1111/j.1440-1681.1979.tb01246.x.

Abstract

The interactions between some drugs that contract and relax airways smooth muscle have been investigated in the cat isolated trachea. 2. Isoprenaline and theophylline inhibited serotonin-elicited contractions more than acetylcholine-mediated responses. This was observed both in terms of the degree of inhibition and the concentration of the relaxant drug producing this inhibition. 3. The acetylcholine- and serotonin-induced contractions were inhibited more by theophylline than by isoprenaline displaced acetylcholine and serotonin response curves to the right whereas theophylline caused a flattening of the curves. 4. Isoprenaline was more effective in hibiting serotonin contractions than acetylcholine contractions when the tracheas were bathed in K+ depolarizing solution, suggesting that the difference in the suscepbibility of serotonin and acetylcholine contractions to isoprenaline was not dependent on the electrical membrane potential. 5. Isoprenaline inhibited the tonic component of acetylcholine contractions more than the phasic component. 6. The differences in the pharmacological responses to the contractile and relaxant drugs in cat tracheal preparations provide further examples in smooth muscle of different mechanisms by which acetylcholine and serotonin induce contraction and isoprenaline and theophylline relaxation.

摘要

已在猫离体气管中研究了一些使气道平滑肌收缩和舒张的药物之间的相互作用。2. 异丙肾上腺素和茶碱对血清素引发的收缩的抑制作用比对乙酰胆碱介导的反应的抑制作用更强。无论是从抑制程度还是产生这种抑制作用的舒张药物浓度方面，均观察到了这一点。3. 茶碱对乙酰胆碱和血清素诱导的收缩的抑制作用比异丙肾上腺素更强，异丙肾上腺素使乙酰胆碱和血清素反应曲线右移，而茶碱则使曲线变平。4. 当气管浸浴在钾离子去极化溶液中时，异丙肾上腺素对血清素收缩的抑制作用比对乙酰胆碱收缩的抑制作用更有效，这表明血清素和乙酰胆碱收缩对异丙肾上腺素敏感性的差异并不取决于膜电位。5. 异丙肾上腺素对乙酰胆碱收缩的强直成分的抑制作用比对相性成分的抑制作用更强。6. 猫气管制剂中对收缩和舒张药物的药理反应差异为乙酰胆碱和血清素诱导收缩以及异丙肾上腺素和茶碱诱导舒张的不同机制在平滑肌中提供了更多实例。