Lucraft H H
Clin Radiol. 1979 Sep;30(5):585-9. doi: 10.1016/s0009-9260(79)80204-4.
The records of 33 cases of ovarian dysgerminoma seen in Manchester between 1943 and 1977 are reviewed, including details of presenting features, age distribution, treatment and survival. The five-year survival rate is 85%. All the Stage I cases and all patients under the age of 20 years at presentation have survived. The cases of the five patients who died are analysed in detail. From this series and review of other series it is concluded that young patients with unilateral Stage I desease who have had a total resection should be carefully followed and radiotherapy reserved for recurrent disease. This does not appear to affect their high chance of cure and enable patients who remain disease-free to retain one functioning ovary. All other patients should have surgery followed by radiotherapy to the whole abdomen. Analysis of the five deaths suggested that, even in Stage III disease a surgical attempt should be made to remove the bulk of the tumour and that the abdominal radiotherapy dose should not be less than 3000 rad in 20 treatments in 28 days.
回顾了1943年至1977年间在曼彻斯特所见的33例卵巢无性细胞瘤病例，包括临床表现、年龄分布、治疗及生存情况的详细资料。五年生存率为85%。所有Ⅰ期病例及所有就诊时年龄在20岁以下的患者均存活。对死亡的5例患者的病例进行了详细分析。从本系列病例及对其他系列病例的回顾得出结论，对于单侧Ⅰ期疾病且已行全切除的年轻患者，应密切随访，放疗应留待复发病例。这似乎并不影响其高治愈几率，并能使无病患者保留一个功能正常的卵巢。所有其他患者均应先接受手术，然后对全腹进行放疗。对5例死亡病例的分析表明，即使是Ⅲ期疾病，也应尝试手术切除大部分肿瘤，且腹部放疗剂量在28天内分20次进行不应少于3000拉德。
