甲吲噻腙及其他药物对小鼠体外造血集落形成的影响。
Effect of methisazone and other drugs on mouse hemophoietic colony formation in vitro.
作者信息
McNeill T A
出版信息
Antimicrob Agents Chemother. 1972 Jan;1(1):6-11. doi: 10.1128/AAC.1.1.6.
Abstract
Methisazone (N-methylisatin beta-thiosemicarbazone) was shown to inhibit the development of hemopoietic colonies in vitro when incorporated in the culture medium. The activity of methisazone was compared with that of several antimetabolic and antibiotic drugs. Although methisazone reduced the number of colonies, it did not affect the size of those colonies which did develop, and evidence is presented which shows that it acted only at the early stages of colony development. Some implications of these findings are briefly discussed.
摘要
甲吲噻腙（N-甲基异吲哚-β-硫代半卡巴腙）被证明，当添加到培养基中时，可在体外抑制造血集落的形成。将甲吲噻腙的活性与几种抗代谢药和抗生素进行了比较。虽然甲吲噻腙减少了集落数量，但并未影响已形成集落的大小，并且有证据表明它仅在集落发育的早期阶段起作用。简要讨论了这些发现的一些意义。
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