抗生素双霉素A对肽聚糖合成的抑制作用。
Inhibition of peptidoglycan synthesis by the antibiotic diumycin A.
作者信息
Lugtenberg E J, Hellings J A, van de Berg G J
出版信息
Antimicrob Agents Chemother. 1972 Dec;2(6):485-91. doi: 10.1128/AAC.2.6.485.
Abstract
Diumycin A, a new antibiotic, was found to inhibit cell wall synthesis by Staphylococcus aureus, a phenomenon accompanied by accumulation of uridine-5'-diphosphate-N-acetyl-muramyl-pentapeptide. The antibiotic inhibited in vitro peptidoglycan synthesis by particulate preparations of Bacillus stearothermophilus and Escherichia coli by preventing the utilization of N-acetyl-glucosamine-N-acetyl-muramyl-pentapeptide. In contrast to vancomycin, the antibiotics diumycin, prasinomycin, moenomycin, 11.837 RP, and enduracidin do not inhibit particulate d-alanine carboxypeptidase.
摘要
新抗生素迪尤霉素A被发现可抑制金黄色葡萄球菌细胞壁的合成，此现象伴随着尿苷-5'-二磷酸-N-乙酰胞壁酰五肽的积累。该抗生素通过阻止N-乙酰葡糖胺-N-乙酰胞壁酰五肽的利用，在体外抑制嗜热脂肪芽孢杆菌和大肠杆菌的颗粒制剂的肽聚糖合成。与万古霉素不同，抗生素迪尤霉素、prasinomycin、莫能菌素、11.837 RP和耐久霉素不抑制颗粒性D-丙氨酸羧肽酶。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 1967 Mar;57(3):767-73. doi: 10.1073/pnas.57.3.767.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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BAGSHAPED MACROMOLECULES--A NEW OUTLOOK ON BACTERIAL CELL WALLS.袋状大分子——对细菌细胞壁的新视角
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Biosynthesis of the peptidoglycan of bacterial cell walls. I. Utilization of uridine diphosphate acetylmuramyl pentapeptide and uridine diphosphate acetylglucosamine for peptidoglycan synthesis by particulate enzymes from Staphylococcus aureus and Micrococcus lysodeikticus.细菌细胞壁肽聚糖的生物合成。I. 金黄色葡萄球菌和溶壁微球菌的颗粒酶利用尿苷二磷酸乙酰胞壁酰五肽和尿苷二磷酸乙酰葡糖胺进行肽聚糖合成。
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[Moenomycin, IV. Acid hydrolysis and characterisation of the cleavage product].[莫能菌素，IV。裂解产物的酸水解及特性鉴定]
Justus Liebigs Ann Chem. 1967;707:170-6. doi: 10.1002/jlac.19677070124.
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