加迪霉素，一种新型的抑制肽聚糖合成的抗生素。
Gardimycin, a new antibiotic inhibiting peptidoglycan synthesis.
作者信息
Somma S, Merati W, Parenti F
出版信息
Antimicrob Agents Chemother. 1977 Mar;11(3):396-401. doi: 10.1128/AAC.11.3.396.
Abstract
Gardimycin, a new antibiotic, at 100 mug/ml, specifically inhibited cell wall synthesis and induced accumulation of uridine 5'-diphosphate-N-acetylmur-amylpentapeptide in whole cells of Bacillus subtilis. The antibiotic was active in a particulate enzyme preparation from Bacillus stearothermophilus: 60 mug/ml caused 50%, and 200mug/ml caused 100%, inhibition of peptidoglycan synthesis. Suppression of peptidoglycan synthesis was accompanied by parallel accumulation of the lipid intermediate. This mechanism of action is discussed in comparison with those of other antibiotics that are known to inhibit bacterial cell wall biosynthesis.
摘要
新抗生素加迪霉素在浓度为100微克/毫升时，能特异性抑制枯草芽孢杆菌全细胞的细胞壁合成，并诱导尿苷5'-二磷酸-N-乙酰胞壁酰五肽的积累。该抗生素对嗜热脂肪芽孢杆菌的颗粒酶制剂有活性：60微克/毫升导致50%的抑制，200微克/毫升导致100%的抑制，抑制肽聚糖合成。肽聚糖合成的抑制伴随着脂质中间体的平行积累。本文将这种作用机制与其他已知抑制细菌细胞壁生物合成的抗生素的作用机制进行了比较。
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