Loke Y W, Pepys M B
Am J Obstet Gynecol. 1975 Jan 1;121(1):37-40. doi: 10.1016/0002-9378(75)90971-0.
The effects on complement in vitro by several commercial preparation of human chorionic gonadotropin (HCG) were investigated. These preparations were demonstrably anticomplementary and produced marked conversion of the third component of complement (C'3). However, detailed analyses showed that the anticomplementary activity was because of the presence of immunoglobulins in the HCG preparations. In view of the known modifying effects of C'3-reactive agents on skin allograft survival and of antigen-antibody complexes on lymphocyte transformation, it may be necessary to reconsider previous work on the immunosuppressive effects of HCG preparations.
研究了几种市售人绒毛膜促性腺激素（HCG）制剂对体外补体的影响。这些制剂具有明显的抗补体作用，并能使补体第三成分（C'3）发生显著转化。然而，详细分析表明，抗补体活性是由于HCG制剂中存在免疫球蛋白。鉴于已知C'3反应剂对皮肤同种异体移植存活的调节作用以及抗原抗体复合物对淋巴细胞转化的作用，可能有必要重新考虑以往关于HCG制剂免疫抑制作用的研究。
