Wise J K, Hendler R, Felig P
Science. 1972 Nov 3;178(4060):513-4. doi: 10.1126/science.178.4060.513.
The increase in concentration of glucagon in plasma caused by infusion of alanine was reduced in obese subjects as compared to that in nonobese control subjects. This was true when the subjects were in the postabsorptive state as well as after an 84-hour fast, at which time the basal glucagon concentration had risen in the nonobese subjects, but remained unaltered in the obese group.
与非肥胖对照受试者相比，肥胖受试者中由输注丙氨酸引起的血浆胰高血糖素浓度升高有所降低。当受试者处于吸收后状态以及禁食84小时后，情况都是如此，此时非肥胖受试者的基础胰高血糖素浓度有所上升，但肥胖组的基础胰高血糖素浓度保持不变。
