Johnson H A, Pavelec M
Am J Pathol. 1972 Oct;69(1):119-30.
Background noise due to random thermal perturbations of molecules has a disruptive effect on all information handling systems, including cells and organisms. This thermal noise appears to be largely responsible for the spontaneous loss of proliferative cells in cell cultures. The rates at which proliferative cells are lost as a result of heat injury, in cultured hamster cells, have been measured at high temperatures and extrapolated down to 37 C. This gives an expected 0.2% loss per hour due to thermal injury at physiologic temperature. That such a loss does in fact occur can be shown by comparing cell generation time with population doubling time, when these cells are growing at physiologic temperatures. Apparently, internal thermal noise presents a primary hazard to the reliable functioning of the cell quite apart from the insults it receives from its external environment.
分子随机热扰动产生的背景噪声会对包括细胞和生物体在内的所有信息处理系统产生破坏作用。这种热噪声似乎在很大程度上导致了细胞培养中增殖细胞的自发损失。在高温下测量了培养的仓鼠细胞因热损伤而损失增殖细胞的速率，并外推至37℃。这表明在生理温度下，由于热损伤，每小时预期会有0.2%的细胞损失。当这些细胞在生理温度下生长时，通过比较细胞生成时间和群体倍增时间，可以证明这种损失确实会发生。显然，内部热噪声对细胞的可靠功能构成了主要危害，这与细胞从外部环境受到的损伤无关。
