Lorente P, Kedra W, Masquet C, Azancot I, Beaufils P
Eur J Cardiol. 1979 Jul;10(1):19-35.
Initial hemodynamics were studied in 101 patients with acute myocardial infarction complicated by shock or left heart failure. 59 had anterior myocardial infarction (AMI); 42 had inferior myocardial infarction (IMI). Data were processed by univariate analysis and correspondence analysis. AMIs and IMIs were significantly different on conduction disturbances, heart rate, left ventricular filling pressure, mean pulmonary artery pressure and right ventricular function indices. Both patients and parameters were projected on the most meaningful factorial plane generated by correspondence analysis. This two-dimensional graphical representation showed that all the information was roughly distributed along the 2 orthogonal axes defining this plane. Survivors and nonsurvivors were fairly well separated along the first factorial axis (prognostic axis) which was highly correlated with both outcome and left ventricular function parameters. AMIs and IMIs were grossly separated along the second factorial axis (topographical axis) which was rather well correlated with location and right ventricular function parameters. These studies suggest that AMI and IMI hemodynamic profiles are modulated by the presence or absence of right ventricular dysfunction. Moreover right ventricular dysfunction may be held responsible of some lack of information about left ventricular function status.
对101例并发休克或左心衰竭的急性心肌梗死患者进行了初始血流动力学研究。其中59例为前壁心肌梗死（AMI）；42例为下壁心肌梗死（IMI）。数据采用单因素分析和对应分析进行处理。AMI和IMI在传导障碍、心率、左心室充盈压、平均肺动脉压和右心室功能指标方面存在显著差异。将患者和参数投影到对应分析生成的最有意义的因子平面上。这种二维图形表示表明，所有信息大致沿定义该平面的2个正交轴分布。存活者和非存活者在第一因子轴（预后轴）上相当清晰地分开，该轴与预后和左心室功能参数高度相关。AMI和IMI在第二因子轴（地形轴）上大致分开，该轴与梗死部位和右心室功能参数相关性较好。这些研究表明，AMI和IMI的血流动力学特征受右心室功能障碍存在与否的调节。此外，右心室功能障碍可能是导致一些关于左心室功能状态信息缺乏的原因。
