神经降压素对大鼠血浆胆固醇水平的影响。

The effect of neurotensin on the plasma cholesterol levels in the rat.

作者信息

Peric-Golia L, Gardner C F, Peric-Golia M

出版信息

Eur J Pharmacol. 1979 May 15;55(4):407-9. doi: 10.1016/0014-2999(79)90116-x.

Abstract

The effect of the hypothalamic tridecapeptide neurotensin (NT) on the plasma cholesterol levels was studied in the rat. 15 min after the intravenous administration of 1.25 pmol/100 g body weight NT, the concentration of the total plasma cholesterol was increased about 25% above the control values (P less than 0.001) and remained at about the same level 30 min after the injection. The hypercholesterolemic response to the intravenous administration of NT increased dose dependently (12.5 and 125 pmol). Adrenalectomy and hypophysectomy did not modify the hypercholesterolemic effect of NT. The data suggest that NT may have a role in cholesterol transport.

摘要

研究了下丘脑十三肽神经降压素（NT）对大鼠血浆胆固醇水平的影响。静脉注射1.25 pmol/100 g体重的NT后15分钟，血浆总胆固醇浓度比对照值升高约25%（P小于0.001），注射后30分钟保持在大致相同水平。静脉注射NT后的高胆固醇血症反应呈剂量依赖性增加（12.5和125 pmol）。肾上腺切除术和垂体切除术并未改变NT的高胆固醇血症作用。数据表明，NT可能在胆固醇转运中起作用。