前列腺素E1和吲哚美辛对豚鼠回肠纵行肌对胆囊收缩素反应的影响。

Effect of prostaglandin E1 and indomethacin on responses of longitudinal muscle of guinea-pig ileum to cholecystokinin.

作者信息

Zséli J, Török T L, Vizi S E, Knoll J

出版信息

Eur J Pharmacol. 1979 Jun;56(1-2):139-44. doi: 10.1016/0014-2999(79)90443-6.

Abstract

The effect of prostaglandin E1 (PGE1) and indomethacin (IND) cholecystokinin (CCK)-induced contractions of guinea-pig isolated ileum longitudinal muscle were studied. PGE1 (2.8--28 nM) consistently and dose dependently increased the contractions evoked by CCK (indirect muscle stimulation) or by ACh. IND (2.7 microM) decreased the contractions to both compounds and this was reversed with 2.8--7 nM PGE1. Pretreatment of the preparations with phentolamine (2.6 microM) or pretreatment of the animals with reserpine (2 mg/kg i.p. 24 h before killing) did not affect PGE1 potentiation or IND inhibition of CCK-induced contractions. The results indicated that PGE1 potentiated CCK-induced contractions of the longitudinal muscle of guinea-pig ileum by increasing the response to released ACh. Experiments with IND suggested that endogenous PGs may modulate the effect of CCK or related gastrointestinal hormones.

摘要

研究了前列腺素E1（PGE1）和吲哚美辛（IND）对胆囊收缩素（CCK）诱导的豚鼠离体回肠纵肌收缩的影响。PGE1（2.8 - 28 nM）持续且剂量依赖性地增强CCK（间接肌肉刺激）或乙酰胆碱（ACh）诱发的收缩。IND（2.7 microM）降低了对这两种化合物的收缩反应，而2.8 - 7 nM的PGE1可逆转这种作用。用酚妥拉明（2.6 microM）预处理标本或用利血平（处死前24小时腹腔注射2 mg/kg）预处理动物，均不影响PGE1对CCK诱导收缩的增强作用或IND的抑制作用。结果表明，PGE1通过增强对释放的ACh的反应来增强CCK诱导的豚鼠回肠纵肌收缩。IND实验表明，内源性前列腺素可能调节CCK或相关胃肠激素的作用。