Holsapple M P, Blake D E, Yim G K
Prostaglandins Med. 1979 Oct;3(4):215-21. doi: 10.1016/0161-4630(79)90083-1.
The pesticide chlordimeform (CDM) depressed the electrically-induced twitch responses of the guinea pig longitudinal muscle ED50 = 3 X 10(-5)M). Naloxone reversed twitch depression induced by morphine but not by CDM. Phentolamine reversed twitch depression induced by either norepinephrine or clonidine, but not by CDM. PGE2 completely reversed twitch depression induced by either CDM or indomethacin, but only partially reversed twitch depression induced by lidocaine. The actions of CDM best resemble those of the nonsteroidal anti-inflammatory agents. The reversibility of the CDM depression by washing indicates that the guinea pig ileal preparation is a convenient screen for distinguishing reversible from irreversible inhibitors of prostaglandin biosynthesis.
杀虫剂杀虫脒（CDM）可抑制豚鼠纵肌的电诱发抽搐反应（半数有效剂量ED50 = 3×10⁻⁵M）。纳洛酮可逆转吗啡诱导的抽搐抑制，但不能逆转CDM诱导的抽搐抑制。酚妥拉明可逆转去甲肾上腺素或可乐定诱导的抽搐抑制，但不能逆转CDM诱导的抽搐抑制。前列腺素E2可完全逆转CDM或吲哚美辛诱导的抽搐抑制，但只能部分逆转利多卡因诱导的抽搐抑制。CDM的作用最类似于非甾体抗炎药。通过冲洗可使CDM诱导的抑制作用逆转，这表明豚鼠回肠制备物是区分前列腺素生物合成可逆性抑制剂和不可逆性抑制剂的便捷筛选模型。
