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血管紧张素II促进钾离子诱发的兔下丘脑3H-去甲肾上腺素的释放。

Angiotensin II facilitates the potassium-evoked release of 3H-noradrenaline from the rabbit hypothalamus.

作者信息

Garcia-Sevilla J A, Dubocovich M L, Langer S Z

出版信息

Eur J Pharmacol. 1979 Jun;56(1-2):173-6. doi: 10.1016/0014-2999(79)90449-7.

DOI:10.1016/0014-2999(79)90449-7
PMID:467506
Abstract

Antiotensin II facilitated in a concentration-dependent manner the potassium-evoked 3H-noradrenaline over-flow from the rabbit hypothalamus. This effect which is probably mediated through presynaptic angiotensin facilitatory receptors on noradrenergic nerve terminals was blocked by the specific angiotensin receptor antagonist, saralasin. These results demonstrate that angiotensin II also facilitates the stimulation-evoked release of noradrenaline in the central nervous system.

摘要

血管紧张素II以浓度依赖的方式促进钾离子诱发的兔下丘脑3H-去甲肾上腺素释放。这种作用可能是通过去甲肾上腺素能神经末梢上的突触前血管紧张素易化受体介导的，特异性血管紧张素受体拮抗剂沙拉新可阻断该作用。这些结果表明，血管紧张素II也促进中枢神经系统中刺激诱发的去甲肾上腺素释放。

相似文献

1
Angiotensin II facilitates the potassium-evoked release of 3H-noradrenaline from the rabbit hypothalamus.血管紧张素II促进钾离子诱发的兔下丘脑3H-去甲肾上腺素的释放。
Eur J Pharmacol. 1979 Jun;56(1-2):173-6. doi: 10.1016/0014-2999(79)90449-7.
2
Facilitatory presynaptic angiotensin receptors on the sympathetic nerves of the human saphenous vein and pulmonary artery. Potential involvement in beta-adrenoceptor-mediated facilitation of noradrenaline release.人隐静脉和肺动脉交感神经上的突触前促进性血管紧张素受体。可能参与β-肾上腺素能受体介导的去甲肾上腺素释放促进作用。
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Effects of angiotensin II on [3H]noradrenaline release and phosphatidylinositol hydrolysis in the parietal cortex and locus coeruleus of the rat.血管紧张素II对大鼠顶叶皮质和蓝斑中[3H]去甲肾上腺素释放及磷脂酰肌醇水解的影响。
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Experimental renal hypertension and [3H]-noradrenaline release from the rabbit hypothalamus: enhanced K+-evoked overflow of tritium and lack of facilitation through presynaptic angiotensin II receptors [proceedings].实验性肾性高血压与家兔下丘脑[3H]-去甲肾上腺素的释放：钾离子诱发的氚溢出增强以及突触前血管紧张素II受体介导的易化作用缺失[会议论文集]
Br J Pharmacol. 1980 Jan;68(1):112P-113P.
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Angiotensin II inhibits the K+-evoked release of [3H]norepinephrine from hypothalamic synaptosomes of the spontaneously hypertensive rat.血管紧张素II抑制自发性高血压大鼠下丘脑突触体中钾离子诱发的[3H]去甲肾上腺素释放。
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Atrial natriuretic factor inhibits noradrenaline release in the presence of angiotensin II and III in the rat hypothalamus.在大鼠下丘脑，心房利钠因子在血管紧张素II和III存在的情况下抑制去甲肾上腺素的释放。
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Facilitation of noradrenaline release by isoprenaline is not mediated by angiotensin II in mouse atria and rat tail artery.在小鼠心房和大鼠尾动脉中，异丙肾上腺素对去甲肾上腺素释放的促进作用并非由血管紧张素II介导。
Arch Int Pharmacodyn Ther. 1989 May-Jun;299:185-99.
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Angiotensin II increases catecholamine release from bovine adrenal medulla but does not enhance that evoked by K+ depolarization or by carbachol.血管紧张素II可增加牛肾上腺髓质中儿茶酚胺的释放，但不能增强由钾离子去极化或卡巴胆碱所诱发的儿茶酚胺释放。
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Modulation of noradrenaline release in the pithed rabbit: a role for angiotensin II.去大脑兔中去甲肾上腺素释放的调节：血管紧张素II的作用。
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Prejunctional angiotensin receptors involved in the facilitation of noradrenaline release in mouse tissues.
参与促进小鼠组织中去甲肾上腺素释放的接头前血管紧张素受体。
Br J Pharmacol. 1999 Jul;127(5):1256-62. doi: 10.1038/sj.bjp.0702652.
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Interaction between presynaptic facilitatory angiotensin II receptors and inhibitory muscarinic cholinoceptors on 3H-noradrenaline release in the rabbit heart.突触前促肾上腺皮质激素释放激素受体与抑制性毒蕈碱胆碱受体对兔心脏3H-去甲肾上腺素释放的相互作用。
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