Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA, 94143, USA.
Department of Anesthesiology, Section on Critical Care Medicine, Wake Forest School of Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.
Crit Care. 2024 Nov 26;28(1):389. doi: 10.1186/s13054-024-05123-7.
Dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II. The panel proposed guidance regarding patient selection and treatment options with exogenous angiotensin II which should trigger further research.
脓毒症中肾素-血管紧张素-醛固酮系统（RAAS）的失调是一种复杂且早期的现象，可能对器官衰竭和患者预后有重大影响。对脓毒性休克中 RAAS 的病理生理学和复杂性有了更好的理解，这导致了外源性血管紧张素 II 的应用作为一种新的治疗药物。在这篇综述中，我们报告了一个关于 RAAS 在脓毒症中的调节作用和影响以及外源性血管紧张素 II 的使用的多国家和多学科专家小组讨论。该小组就外源性血管紧张素 II 的患者选择和治疗方案提出了指导意见，这应该会引发进一步的研究。
