Zetler G, Kampmann E
Eur J Pharmacol. 1979 Jun;56(1-2):21-9. doi: 10.1016/0014-2999(79)90428-x.
The ability of the angiotensin antagonists 1-Sar,8-Ala-angiotensin II (saralasin) and 1-Sar,8-Leu-angiotensin II (sarleusin) and the bradykinin-potentiating peptide B (BPP) to modify the twitch-enhancing effect of angiotensin II, bradykinin, and substance P, was studied in the isolated field-stimulated guinea-pig vas deferens. The twitch-enhancing effect of angiotensin, bradykinin and substance P underwent tachyphylaxis which was strongest after angiotensin. Saralasin and sarleusin were without influence on the twitch response and antagonized the effect of angiotensin, but not that of bradykinin or substance P, respectively. The features of the antagonism to angiotensin were compatible with the notion that saralasin is a competitive and sarleusin a dual antagonist. BPP did modify either the twitch response or the effects of angiotensin, bradykinin, and substance P. In the non-stimulate vas, the contracting effect of noradrenaline did not undergo tachyphylaxis and was not mofified by angiotensin, bradykinin, or substance P. It is concluded that there exist in the guinea-pig vas specific peptide receptors, one of them having the properties of a "typical" angiotensin receptor.
在离体的经场刺激的豚鼠输精管中，研究了血管紧张素拮抗剂1-肌氨酸酐，8-丙氨酸血管紧张素II（沙拉新）和1-肌氨酸酐，8-亮氨酸血管紧张素II（塞勒新）以及缓激肽增强肽B（BPP）对血管紧张素II、缓激肽和P物质的抽搐增强效应的影响。血管紧张素、缓激肽和P物质的抽搐增强效应会发生快速耐受性，其中血管紧张素后的快速耐受性最强。沙拉新和塞勒新对抽搐反应无影响，分别拮抗血管紧张素的效应，但不拮抗缓激肽或P物质的效应。对血管紧张素的拮抗特性符合以下观点：沙拉新是竞争性拮抗剂，塞勒新是双重拮抗剂。BPP既不改变抽搐反应，也不改变血管紧张素、缓激肽和P物质的效应。在未受刺激的输精管中，去甲肾上腺素的收缩效应不发生快速耐受性，也不受血管紧张素、缓激肽或P物质的影响。结论是豚鼠输精管中存在特异性肽受体，其中之一具有“典型”血管紧张素受体的特性。
