小鼠长期给予东莨菪碱后撤药，对毛果芸香碱唾液分泌反应的超敏性。

Supersensitivity of salivation in response to pilocarpine after withdrawal of chronically administered hyoscine in the mouse.

作者信息

Parkes M W, Parks J C

出版信息

Br J Pharmacol. 1972 Oct;46(2):315-23. doi: 10.1111/j.1476-5381.1972.tb06876.x.

DOI:10.1111/j.1476-5381.1972.tb06876.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666336/

Abstract

The duration of the effect of a single large dose of hyoscine, in reducing the salivary response of mice to pilocarpine, was established as less than 66 hours.2. Supersensitivity was observed, after daily oral dosing with hyoscine, in the increased salivation of mice in response to pilocarpine injected at least 66 h after withdrawing hyoscine.3. The minimum duration of pretreatment with hyoscine that resulted in supersensitivity was 5 days. The daily dose was more effective if divided.4. The period after withdrawal for which supersensitivity could be detected was 6 days.5. The maximum salivary response to pilocarpine was increased by chronic hyoscine pretreatment.6. The antagonism of a single dose of hyoscine to pilocarpine salivation, as expressed by the dose-ratio of pilocarpine, was not altered by chronic hyoscine pre-treatment.

摘要

单次大剂量东莨菪碱减少小鼠对毛果芸香碱唾液分泌反应的作用持续时间确定为少于66小时。
每日口服东莨菪碱后，在撤药至少66小时后注射毛果芸香碱时，观察到小鼠唾液分泌增加，即出现超敏反应。
导致超敏反应的东莨菪碱预处理最短持续时间为5天。每日剂量分次给药更有效。
撤药后可检测到超敏反应的时间段为6天。
长期东莨菪碱预处理可增加对毛果芸香碱的最大唾液分泌反应。
单次剂量东莨菪碱对毛果芸香碱唾液分泌的拮抗作用，以毛果芸香碱的剂量比表示，不受长期东莨菪碱预处理的影响。