Mirakhur R K
Br J Anaesth. 1978 Jun;50(6):591-8. doi: 10.1093/bja/50.6.591.
The effects of equivalent doses of atropine and hyoscine following oral and i.m. administration were assessed on salivary secretion, heart rate, arterial pressure, body temperature, pupillary size, near-point of vision and sweat-gland activity. The ratio of oral to i.m. doses of atropine on heart rate and salivary secretion appears to be 2:1 and that of hyoscine on salivary secretion about 5-6:1. Following oral administration the effects on the eye are minimal even after the highest doses of the two drugs, while the decrease in salivation is adequate.
评估了口服和肌内注射等效剂量的阿托品和东莨菪碱后，它们对唾液分泌、心率、动脉血压、体温、瞳孔大小、近点视力和汗腺活动的影响。阿托品口服与肌内注射剂量对心率和唾液分泌的比例似乎为2:1，而东莨菪碱对唾液分泌的比例约为5 - 6:1。口服给药后，即使使用两种药物的最高剂量，对眼睛的影响也很小，而唾液分泌的减少是足够的。
