Lebedeva E S, Danilov L N, Aganezov S A, Laskin G M
Fiziol Zh SSSR Im I M Sechenova. 1979 Jun;65(6):881-6.
High pressure in the lung artery was maintained with the aid of i. v. serotonin administration (0.5 mg/ml) in dogs during 10 min. The simultaneous increase of the intravascular pressure in minor circulation and of the lung volume circulation was followed by an increasing blood volume in lungs, diffusion capacity of lungs, oxygen tension in the arterial blood, and satiation of the latter with oxygen. The combined action of the above two hemodynamic factors aids to opening of latent vascular areas, to a more regular distribution of perfusion over the lung areas according to the ventilation level. This mechanism seems to be one of the first compensatory responses to disturbances in the lung gas exchange.
在狗身上，通过静脉注射血清素（0.5毫克/毫升）维持肺动脉高压10分钟。小循环中血管内压力和肺容积循环同时增加，随后肺内血容量、肺扩散容量、动脉血氧张力以及动脉血的氧饱和度均增加。上述两个血流动力学因素的联合作用有助于潜在血管区域的开放，使灌注根据通气水平在肺区域更均匀地分布。这种机制似乎是对肺气体交换紊乱的首批代偿反应之一。
